nlmixr2autoinit: Automatic Generation of Initial Estimates for Population
Pharmacokinetic Modeling
Provides automated methods for generating initial parameter estimates
in population pharmacokinetic modeling. The pipeline integrates adaptive single-point
methods, naive pooled graphic approaches, noncompartmental analysis methods, and parameter
sweeping across pharmacokinetic models. It estimates residual unexplained variability
using either data-driven or fixed-fraction approaches and assigns pragmatic initial values
for inter-individual variability. These strategies are designed to improve model
robustness and convergence in 'nlmixr2' workflows. For more details see
Huang Z, Fidler M, Lan M, Cheng IL, Kloprogge F, Standing JF (2025)
<doi:10.1007/s10928-025-10000-z>.
| Version: |
1.0.0 |
| Depends: |
nlmixr2data, R (≥ 4.0) |
| Imports: |
nlmixr2, nlmixr2est, rxode2, dplyr, tidyr, crayon, purrr, knitr, magrittr, progressr, tibble, vpc |
| Published: |
2025-11-13 |
| DOI: |
10.32614/CRAN.package.nlmixr2autoinit (may not be active yet) |
| Author: |
Zhonghui Huang [aut, cre],
Joseph Standing [ctb],
Matthew Fidler [ctb],
Frank Kloprogge [ctb] |
| Maintainer: |
Zhonghui Huang <huangzhonghui22 at gmail.com> |
| BugReports: |
https://github.com/ucl-pharmacometrics/nlmixr2autoinit/issues |
| License: |
GPL (≥ 3) |
| URL: |
https://github.com/ucl-pharmacometrics/nlmixr2autoinit |
| NeedsCompilation: |
no |
| Language: |
en-US |
| CRAN checks: |
nlmixr2autoinit results |
Documentation:
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