## ----include=FALSE------------------------------------------------------------ knitr::opts_chunk$set( collapse = TRUE, comment = "#>", dev = "svg", fig.ext = "svg", fig.width = 7.2916667, fig.asp = 0.618, fig.align = "center", out.width = "80%" ) ## ----------------------------------------------------------------------------- library(gsDesign) library(gsDesignTune) ## ----------------------------------------------------------------------------- job <- gsDesignTune( k = 3, test.type = 2, alpha = 0.025, beta = 0.10, timing = tune_values(list(c(0.33, 0.67, 1), c(0.5, 0.75, 1))), upper = SpendingFamily$new( SpendingSpec$new(sfLDOF, par = tune_fixed(0)), SpendingSpec$new(sfHSD, par = tune_seq(-4, 4, length_out = 3)) ) ) job$run(strategy = "grid", parallel = FALSE) res <- job$results() head(res) ## ----------------------------------------------------------------------------- best <- job$best("final_n", direction = "min") head(best, 10) ## ----------------------------------------------------------------------------- job$plot(metric = "final_n", x = "upper_par", color = "upper_fun") ## ----------------------------------------------------------------------------- job_surv <- gsSurvTune( k = 3, test.type = 4, alpha = 0.025, beta = 0.10, timing = tune_values(list(c(0.33, 0.67, 1), c(0.5, 0.75, 1))), hr = tune_seq(0.60, 0.75, length_out = 3), upper = SpendingFamily$new( SpendingSpec$new(sfLDOF, par = tune_fixed(0)), SpendingSpec$new(sfHSD, par = tune_seq(-4, 4, length_out = 3)) ), lower = SpendingSpec$new(sfLDOF, par = tune_fixed(0)), lambdaC = log(2) / 6, eta = 0.01, gamma = c(2.5, 5, 7.5, 10), R = c(2, 2, 2, 6), T = 18, minfup = 6, ratio = 1 ) job_surv$run(strategy = "grid", parallel = FALSE) res_surv <- job_surv$results() head(res_surv) ## ----------------------------------------------------------------------------- job_cal <- gsSurvCalendarTune( test.type = 4, alpha = 0.025, beta = 0.10, calendarTime = tune_values(list(c(12, 24, 36), c(9, 18, 27))), spending = tune_choice("information", "calendar"), hr = tune_seq(0.60, 0.75, length_out = 3), upper = SpendingFamily$new( SpendingSpec$new(sfLDOF, par = tune_fixed(0)), SpendingSpec$new(sfHSD, par = tune_seq(-4, 4, length_out = 3)) ), lower = SpendingSpec$new(sfLDOF, par = tune_fixed(0)), lambdaC = log(2) / 6, eta = 0.01, gamma = c(2.5, 5, 7.5, 10), R = c(2, 2, 2, 6), minfup = 18, ratio = 1 ) job_cal$run(strategy = "grid", parallel = FALSE) res_cal <- job_cal$results() head(res_cal) ## ----------------------------------------------------------------------------- best_surv <- job_surv$best("final_events", direction = "min") head(best_surv, 10) ## ----------------------------------------------------------------------------- job_surv$plot(metric = "final_events", x = "hr", color = "upper_fun") ## ----------------------------------------------------------------------------- report_path <- tempfile(fileext = ".html") job_surv$report(report_path) report_path