Bioconductor release scheduled for October 29

scGraphVerse

This is the development version of scGraphVerse; to use it, please install the devel version of Bioconductor.

scGraphVerse: A Gene Regulatory Network Analysis Package


Bioconductor version: Development (3.22)

A package for inferring, comparing, and visualizing gene regulatory networks from single-cell RNA sequencing data. It integrates multiple methods (GENIE3, GRNBoost2, ZILGM, PCzinb, and JRF) for robust network inference, supports consensus building across methods or datasets, and provides tools for evaluating regulatory structure and community similarity. GRNBoost2 requires Python package 'arboreto' which can be installed using init_py(install_missing = TRUE). This package includes adapted functions from ZILGM (Park et al., 2021), JRF (Petralia et al., 2015), and learn2count (Nguyen et al. 2023) packages with proper attribution under GPL-2 license.

Author: Francesco Cecere [aut, cre] ORCID iD ORCID: 0000-0002-0329-0870 , Annamaria Carissimo [aut], Daniela De Canditiis [aut], Claudia Angelini [aut, fnd]

Maintainer: Francesco Cecere <francesco.cecerengs at gmail.com>

Citation (from within R, enter citation("scGraphVerse")):

Installation

To install this package, start R (version "4.5") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("scGraphVerse")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

Reference Manual PDF

Details

biocViews GeneRegulation, GeneSetEnrichment, GraphAndNetwork, KEGG, Network, NetworkEnrichment, NetworkInference, Pathways, RNASeq, Reactome, Sequencing, SingleCell, Software, Visualization
Version 0.99.19
In Bioconductor since BioC 3.22 (R-4.5)
License GPL-3 + file LICENSE
Depends R (>= 4.5.0)
Imports BiocBaseUtils, BiocParallel(>= 1.30.0), doParallel, doRNG, GENIE3, Matrix, MultiAssayExperiment, SingleCellExperiment, SummarizedExperiment, distributions3, dplyr, grDevices, graphics, httr, igraph, jsonlite, methods, parallel, reticulate, tidyr, glmnet, MASS, utils, stats, S4Vectors, graph, mpath
System Requirements Python (>= 3.6) and arboreto Python package for GRNBoost2 method. Use init_py(install_missing = TRUE) for automated installation.
URL https://ngsFC.github.io/scGraphVerse
Bug Reports https://github.com/ngsFC/scGraphVerse/issues
See More
Suggests AnnotationDbi, clusterProfiler, DOSE, enrichplot, fmsb, ggplot2, ggraph, gridExtra, INetTool, org.Hs.eg.db, org.Mm.eg.db, patchwork, pROC, RColorBrewer, ReactomePA, rentrez, robin, scales, Seurat, STRINGdb, testthat (>= 3.0.0), knitr, rmarkdown, tidyverse, magick, celldex, SingleR, TENxPBMCData, scater, GenomeInfoDb, GenomicRanges
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package
Windows Binary (x86_64)
macOS Binary (x86_64) scGraphVerse_0.99.19.tgz
macOS Binary (arm64) scGraphVerse_0.99.19.tgz
Source Repository git clone https://git.bioconductor.org/packages/scGraphVerse
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/scGraphVerse
Bioc Package Browser https://code.bioconductor.org/browse/scGraphVerse/
Package Short Url https://bioconductor.org/packages/scGraphVerse/
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